Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …

Dendritic cells (DCs) are a heterogeneous group of antigen-presenting innate immune cells
that regulate adaptive immunity, including against cancer. Therefore, understanding the …

Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation,
trafficking and function. Monocyte-derived DCs pulsed with tumor antigens have been tested …

T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) is an important
immune checkpoint molecule initially identified as a marker of IFN-γ–producing CD4+ and …

Despite the success of immunotherapy, overcoming immunoresistance in cancer remains
challenging. We identified a unique niche of tumor-associated macrophages (TAMs) …

Chemokines are a class of small cytokines or signaling proteins that are secreted by cells.
Owing to their ability to induce directional chemotaxis of nearby responding cells, they are …

Abstract Background Dendritic cells (DCs) mediate divergent immune effects by activating T
cells or negatively regulating the immune response to promote immune tolerance. They …

Cytotoxic CD8+ T cells are potent killers of diseased cells, but their functional capacity is
often compromised in cancer. The quality of antitumor T cell immunity is determined during T …

Cancer immunotherapies, in particular checkpoint blockade immunotherapy (CBT), can
induce control of cancer growth, with a fraction of patients experiencing durable responses …

Erythroblastic islands (EBIs) are the specialized structures for erythropoiesis, but they have
never been found functional in tumors. As the most common pediatric liver malignancy …