Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …

The immune system is highly complex and distributed throughout an organism, with
hundreds to thousands of cell states existing in parallel with diverse molecular pathways …

Immune checkpoint inhibitors (ICIs) have yielded remarkable responses but often lead to
immune-related adverse events (irAEs). Although germline causes for irAEs have been …

DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic
response. We systematically analyzed somatic alterations to provide a comprehensive view …

INTRODUCTION Cancer is a leading cause of death worldwide, and there is great need to
define the molecular mechanisms driving the development and progression of individual …

We present recount3, a resource consisting of over 750,000 publicly available human and
mouse RNA sequencing (RNA-seq) samples uniformly processed by our new Monorail …

The advent of Next-Generation Sequencing (NGS) technologies has opened new
perspectives in deciphering the genetic mechanisms underlying complex diseases …

RNA sequencing (RNA-seq) is the leading technology for genome-wide transcript
quantification. However, publicly available RNA-seq data is currently provided mostly in raw …

Widespread changes to DNA methylation and chromatin are well documented in cancer, but
the fate of higher-order chromosomal structure remains obscure. Here we integrated …

Background In high-throughput studies, hundreds to millions of hypotheses are typically
tested. Statistical methods that control the false discovery rate (FDR) have emerged as …