Squaramides represent a class of vinylogous amides that are derived from the squarate
oxocarbon dianion. While they have been known since the 1950s, squaramides have only …

Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Benznidazole and nifurtimox are the two approved drugs for their treatment, but both …

Tacrine was the first drug to be approved for Alzheimer's disease (AD) treatment, acting as a
cholinesterase inhibitor. The neuropathological hallmarks of AD are amyloid-rich senile …

Introduction Chagas disease is a neglected, endemic disease in 21 countries, spreading to
non-endemic countries too. Like other neglected diseases affecting primarily low-and middle …

Introduction: Diseases caused by protozoa are one of the leading causes of death
worldwide, especially in tropical regions such as Brazil. Chagas disease, leishmaniasis, and …

The biological and medicinal chemistry of the oxocarbon acids 2, 3-dihydroxycycloprop-2-en-
1-one (deltic acid), 3, 4-dihydroxycyclobut-3-ene-1, 2-dione (squaric acid), 4, 5-dihydroxy-4 …

Trypanosomatidae is a family of unicellular parasites belonging to the phylum Euglenozoa,
which are causative agents in high impact human diseases such as Leishmaniasis, Chagas …

Chagas disease (CD) is a tropical and potentially fatal infection caused by Trypanosoma
cruzi. Although CD was limited to Latin America as a silent disease, CD has become …

Chagas disease (CD), or American trypanosomiasis, caused by the parasitic protozoa
Trypanosoma cruzi, is a substantial global health burden. This comprehensive review …

O artigo examina um novo tipo de tensão, identificada na filosofia das práticas científicas,
entre a pretensão de desenvolver uma ciência imparcial eo fato aceito de que valores não …