Decades of research has recognized a solid role for Pim kinases in lymphoproliferative
disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling …

PIM (proviral integration site for moloney murine leukemia virus) kinase plays a key role as
an oncogene in various cancers including myeloma, leukemia, prostate and breast cancers …

Proviral integration site for Moloney murine leukemia virus-1 (Pim-1) is a serine/threonine
kinase that regulates multiple cellular functions such as cell cycle, cell survival, drug …

Proviral integration sitea for Moloney-murine leukemia virus (PIM) kinases are a family of
highly conserved serine/tyrosine kinases consisting of three members, PIM-1, PIM-2, and …

Background/Aims: Natural compounds are a promising resource for anti-tumor drugs.
Myricetin, an abundant flavonoid found in the bark and leaves of bayberry, shows multiple …

In recent years, natural products have increasingly attracted more attention because of their
potential anticancer activity and low intrinsic toxicity. Hispidulin is a natural flavonoid with a …

The PIM Kinases belong to the family of a proto-oncogene that essentially phosphorylates
the serine/threonine residues of the target proteins. They are primarily categorized into three …

Background PIM kinases are well-studied drug targets for cancer, belonging to
Serine/Threonine kinases family. They are the downstream target of various signaling …

Colorectal cancer (CRC) accounts for over 600 000 deaths annually worldwide. The current
study aims to evaluate the value of proto‐oncogene PIM 1 as a therapeutic target in CRC …

PIM kinases, a serine/threonine kinase family with three isoforms, has been well-known to
participate in multiple physiological processes by phosphorylating various downstream …