Evidence from biochemistry, genetics, and electron microscopy strongly supports the idea
that a ring of Synaptotagmin is central to the clamping and release of synaptic vesicles (SVs) …

Munc13-1 is essential for vesicle docking and fusion at the active zone of synapses. Here,
we report that Munc13-1 self-assembles into molecular clusters within diacylglycerol-rich …

It has long been thought that exocytosis was driven exclusively by well-studied fusion
proteins. Some decades ago, the role of lipids became evident and escalated interest in the …

At the synapse, presynaptic neurotransmitter release is tightly controlled by release
machinery, involving the soluble N-ethylmaleimide–sensitive factor attachment protein …

Neurotransmitters are released from synaptic vesicles with remarkable precision in
response to presynaptic calcium influx but exhibit significant heterogeneity in exocytosis …

The critical presynaptic protein Munc13 serves numerous roles in the process of docking
and priming synaptic vesicles. Here we investigate the functional significance of two distinct …

The poet WB Yeats wrote that" All that is personal soon rots, it must be packed in ice or salt".
Here we show that in Caenorhabditis elegans nematodes, simple animals with just 302 …

Neurotransmitters are released from synaptic vesicles with remarkable precision in
response to presynaptic Ca 2+ influx but exhibit significant heterogeneity in exocytosis …

Abstract Synaptotagmin 7 (Syt-7) is part of the synaptotagmin protein family that regulates
exocytotic lipid membrane fusion. Among the family, Syt-7 stands out by its membrane …

Neurotransmitters are released from synaptic vesicles with remarkable precision in
response to presynaptic Ca 2+ influx but exhibit significant heterogeneity in exocytosis …