Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release

H Zhang, M Lei, Y Zhang, H Li, Z He, S Xie, L Zhu… - Science …, 2024 - science.org
At the synapse, presynaptic neurotransmitter release is tightly controlled by release
machinery, involving the soluble N-ethylmaleimide–sensitive factor attachment protein …

Minimal presynaptic protein machinery governing diverse kinetics of calcium-evoked neurotransmitter release

D Bose, M Bera, CA Norman, Y Timofeeva… - Nature …, 2024 - nature.com
Neurotransmitters are released from synaptic vesicles with remarkable precision in
response to presynaptic calcium influx but exhibit significant heterogeneity in exocytosis …

A tunable and druggable mechanism to delay forgetting of olfactory memories in C. elegans

D Landschaft-Berliner, K Goldstein, G Teichman… - BioRxiv, 2024 - biorxiv.org
The poet WB Yeats wrote that" All that is personal soon rots, it must be packed in ice or salt".
Here we show that in Caenorhabditis elegans nematodes, simple animals with just 302 …

[HTML][HTML] A minimal presynaptic protein machinery mediating synchronous and asynchronous exocytosis and short-term plasticity

D Bose, M Bera, CA Norman, Y Timofeeva, KE Volynski… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Neurotransmitters are released from synaptic vesicles with remarkable precision in
response to presynaptic Ca 2+ influx but exhibit significant heterogeneity in exocytosis …

[HTML][HTML] Synaptotagmin 7 C2 domains induce membrane curvature stress via electrostatic interactions and the wedge mechanism

AH Beaven, V Bikkumalla, NL Chon, AE Matthews… - Biorxiv, 2024 - ncbi.nlm.nih.gov
Abstract Synaptotagmin 7 (Syt-7) is part of the synaptotagmin protein family that regulates
exocytotic lipid membrane fusion. Among the family, Syt-7 stands out by its membrane …

A minimal presynaptic protein machinery mediating synchronous and asynchronous exocytosis and short-term plasticity

S Krishnakumar, D Bose, M Bera, C Norman… - 2024 - researchsquare.com
Neurotransmitters are released from synaptic vesicles with remarkable precision in
response to presynaptic Ca 2+ influx but exhibit significant heterogeneity in exocytosis …