The recognition of anions in water remains a key challenge in modern supramolecular
chemistry, and is essential if proposed applications in biological, medical, and …

Nature has devised highly efficient and selective ways of recognizing anionic substrates by
using surprisingly few building blocks the most important of which are the amino acids …

Insulin provides a classical model of a globular protein, yet how the hormone changes
conformation to engage its receptor has long been enigmatic. Interest has focused on the C …

Abstract Die Erkennung von Anionen in Wasser ist auch heute noch für die moderne
supramolekulare Chemie eine schwierige Aufgabe, die aber für Anwendungen in Biologie …

The de novo design of peptides and proteins has emerged as an approach for investigating
protein structure and function. The success relies heavily on the ability to design relatively …

Oligoamide sequences comprised of both 8-amino-2-quinolinecarboxylic acid “Q” and 6-
aminomethyl-2-pyridinecarboxylic acid “P” have been synthesized. It was found that the …

hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers
toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and …

In this second part of our review article on the preferred screw sense and interconversion of
peptide helices, we discuss the most significant computational and experimental data …

Toward delineation of antimicrobial action, a prototypic amphipathic, cationic decapeptide
Ac-GX-RK-X-HK-X-WA-NH2 was designed and peptides for which X was …

Considering how biological macromolecules first evolved, probably within a marine
environment, it seems likely the very earliest peptides were not encoded by nucleic acids, or …