This study aimed to determine the role of transient receptor potential vanilloid 4 (TRPV4), a
calcium (Ca 2+)-permeable cation channel, in the pathophysiology of retinal vascular …

Ouabain, a substance originally obtained from plants, is now classified as a hormone
because it is produced endogenously in certain animals, including humans. However, its …

Ubiquitin (Ub)-mediated regulation of plasmalemmal ion channel activity canonically occurs
via stimulation of endocytosis. Whether ubiquitination can modulate channel activity by …

Activation of the transient receptor potential A1 channel (TRPA1) by electrophilic agonists
was reported to induce the opening of tight junctions (TJs). Because compounds that …

Abstract Ethnopharmacological relevance Houpo Mahuang Decoction (HPMHD is one of
the classic traditional Chinese prescriptions that has been used in the treatment of asthma …

Biophysical cues from the cell microenvironment are detected by mechanosensitive
components at the cell surface. Such machineries convert physical information into …

Matrikines are biologically active peptides generated from fragments fragmentation of
extracellular matrix components (ECM) that are functionally distinct from the original full …

This study aimed to investigate the effects of sulfur dioxide (SO2) derivatives on asthma
induced by ovalbumin (OVA). Sprague Dawley rats were sensitized to and challenged with …

Calcium homeostasis directs various intracellular cascades and therefore strict spatio-
temporal control of calcium influx is also crucial for diverse physiological processes. In the …

抄録 抗体に代表されるバイオ医薬品は, その標的特異性と薬効の高さから市場規模を急速に拡大
している. 一方, バイオ医薬品をはじめとする難吸収性薬剤は生体に対する透過吸収性が低いため …