Sickle cell disease (SCD) is characterized by increased hemolysis, which results in plasma
heme overload and ultimately cardiovascular complications. Here, we hypothesized that …

Mitochondria are the main sources of energy production for muscle tissues, including
skeletal, cardiac, or smooth muscle, to support their activities. Mitochondrial dysfunction and …

The process of aging strongly correlates with maladaptive architectural, mechanical, and
biochemical alterations that contribute to the decline in cardiac function. Consequently …

Targeted therapies of melanoma are of urgent need considering the resistance of this
aggressive type of cancer to chemotherapeutics. The voltage-dependent anion channel 1 …

Aging is a major risk for cardiovascular diseases (CVD). Age-related disorders include
oxidative stress, mitochondria dysfunction, and exacerbation of the NF-κB/NLRP3 innate …

An increase in cardiomyocyte apoptosis is the main contributor to the observed high
morbidity of cardiac disease during aging. Mitochondria play important roles in cardiac …

The symptoms of ageing are somewhat different and can lead to the altered role of the
cardiovascular system at the levels of genetic, biochemical, tissue, organ, and systems …

Background Cardiac apoptosis plays a key role in increased morbidity associated with aging-
induced-cardiac disorder. Mitochondria play an important role in cardiac apoptosis, and …

Cardiac aging is a critical determinant of cardiac dysfunction, which contributes to
cardiovascular disease in the elderly. Proprotein convertase subtilisin/kexin 6 (PCSK6) is a …

Cardiac aging is a multifaceted process that encompasses structural and functional
alterations culminating in heart failure. As the elderly population continues to expand, there …