Excess heme upregulates heme oxygenase 1 and promotes cardiac ferroptosis in mice with sickle cell disease
Sickle cell disease (SCD) is characterized by increased hemolysis, which results in plasma
heme overload and ultimately cardiovascular complications. Here, we hypothesized that …
heme overload and ultimately cardiovascular complications. Here, we hypothesized that …
Targeting mitochondrial quality control in muscle aging: Natural dietary products as potential interventions
Q Chen, W Huang, E Capanoglu, AT Amrouche… - Food …, 2023 - Wiley Online Library
Mitochondria are the main sources of energy production for muscle tissues, including
skeletal, cardiac, or smooth muscle, to support their activities. Mitochondrial dysfunction and …
skeletal, cardiac, or smooth muscle, to support their activities. Mitochondrial dysfunction and …
[HTML][HTML] Keeping the beat against time: mitochondrial fitness in the aging heart
The process of aging strongly correlates with maladaptive architectural, mechanical, and
biochemical alterations that contribute to the decline in cardiac function. Consequently …
biochemical alterations that contribute to the decline in cardiac function. Consequently …
Mitochondrial voltage-dependent anion channel 1–hexokinase-II complex-targeted strategy for melanoma inhibition using designed multiblock peptide amphiphiles
F Zhang, A Angelova, VM Garamus… - … Applied Materials & …, 2021 - ACS Publications
Targeted therapies of melanoma are of urgent need considering the resistance of this
aggressive type of cancer to chemotherapeutics. The voltage-dependent anion channel 1 …
aggressive type of cancer to chemotherapeutics. The voltage-dependent anion channel 1 …
[HTML][HTML] Melatonin/Nrf2/NLRP3 connection in mouse heart mitochondria during aging
Aging is a major risk for cardiovascular diseases (CVD). Age-related disorders include
oxidative stress, mitochondria dysfunction, and exacerbation of the NF-κB/NLRP3 innate …
oxidative stress, mitochondria dysfunction, and exacerbation of the NF-κB/NLRP3 innate …
Decreased dynamin-related protein 1-related mitophagy induces myocardial apoptosis in the aging heart
X Wei, Y Wu, W Wang, S Zhang, D Liu… - Acta Biochimica et …, 2021 - academic.oup.com
An increase in cardiomyocyte apoptosis is the main contributor to the observed high
morbidity of cardiac disease during aging. Mitochondria play important roles in cardiac …
morbidity of cardiac disease during aging. Mitochondria play important roles in cardiac …
Molecular explanation of Wnt/βcatenin antagonist pyrvinium mediated calcium equilibrium changes in aging cardiovascular disorders
The symptoms of ageing are somewhat different and can lead to the altered role of the
cardiovascular system at the levels of genetic, biochemical, tissue, organ, and systems …
cardiovascular system at the levels of genetic, biochemical, tissue, organ, and systems …
Effect of vitamin D on cardiac hypertrophy in D-galactose-induced aging model through cardiac mitophagy
Background Cardiac apoptosis plays a key role in increased morbidity associated with aging-
induced-cardiac disorder. Mitochondria play an important role in cardiac apoptosis, and …
induced-cardiac disorder. Mitochondria play an important role in cardiac apoptosis, and …
[HTML][HTML] Pcsk6 Deficiency Promotes Cardiomyocyte Senescence by Modulating Ddit3-Mediated ER Stress
W Zhan, L Chen, H Liu, C Long, J Liu, S Ding, Q Wu… - Genes, 2022 - mdpi.com
Cardiac aging is a critical determinant of cardiac dysfunction, which contributes to
cardiovascular disease in the elderly. Proprotein convertase subtilisin/kexin 6 (PCSK6) is a …
cardiovascular disease in the elderly. Proprotein convertase subtilisin/kexin 6 (PCSK6) is a …
Unlocking the dark matter: noncoding RNAs and RNA modifications in cardiac aging
J Kang, J Rhee, C Wang, Y Yang… - American Journal of …, 2024 - journals.physiology.org
Cardiac aging is a multifaceted process that encompasses structural and functional
alterations culminating in heart failure. As the elderly population continues to expand, there …
alterations culminating in heart failure. As the elderly population continues to expand, there …