Small RNAs are ubiquitously present regulators in all kingdoms of life. Most bacterial and
archaeal small RNAs (sRNAs) act by antisense mechanisms on multiple target mRNAs …

Our knowledge of gene function has increasingly lagged behind gene discovery, hindering
our understanding of the genetic basis of microbial phenotypes. Recently, however …

Recent advances in high-throughput RNA sequencing (RNA-seq) have enabled
tremendous leaps forward in our understanding of bacterial transcriptomes. However …

SUMMARY A substantial amount of antisense transcription is a hallmark of gene expression
in eukaryotes. However, antisense transcription was first demonstrated in bacteria almost 50 …

Transcriptome-wide studies in eukaryotes have been instrumental in the characterization of
fundamental regulatory mechanisms for more than a decade. By contrast, in prokaryotes …

Abstract Background Structured noncoding RNAs perform many functions that are essential
for protein synthesis, RNA processing, and gene regulation. Structured RNAs can be …

Antisense RNAs encoded on the DNA strand opposite another gene have the potential to
form extensive base-pairing interactions with the corresponding sense RNA. Unlike other …

Quorum sensing (QS) is a process of cell-to-cell communication that enables bacteria to
transition between individual and collective lifestyles. QS controls virulence and biofilm …

Genome-wide studies of bacterial gene expression are shifting from microarray technology
to second generation sequencing platforms. RNA-seq has a number of advantages over …

Background High-throughput sequencing of cDNA libraries (RNA-Seq) has proven to be a
highly effective approach for studying bacterial transcriptomes. A central challenge in …