The human genetic epidemiology of COVID-19
Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
New insights into the alveolar epithelium as a driver of acute respiratory distress syndrome
The alveolar epithelium serves as a barrier between the body and the external environment.
To maintain efficient gas exchange, the alveolar epithelium has evolved to withstand and …
To maintain efficient gas exchange, the alveolar epithelium has evolved to withstand and …
Increased risk of severe clinical course of COVID-19 in carriers of HLA-C* 04: 01
Background Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic,
there has been increasing urgency to identify pathophysiological characteristics leading to …
there has been increasing urgency to identify pathophysiological characteristics leading to …
A harmonized public resource of deeply sequenced diverse human genomes
Z Koenig, MT Yohannes, LL Nkambule… - Genome …, 2024 - genome.cshlp.org
Underrepresented populations are often excluded from genomic studies due in part to a lack
of resources supporting their analyses. The 1000 Genomes Project (1kGP) and Human …
of resources supporting their analyses. The 1000 Genomes Project (1kGP) and Human …
Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals
JA Kosmicki, JE Horowitz, N Banerjee, R Lanche… - The American Journal of …, 2021 - cell.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We …
disease 2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We …
[HTML][HTML] An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia
The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
emphasized the vulnerability of human populations to novel viral pressures, despite the vast …
emphasized the vulnerability of human populations to novel viral pressures, despite the vast …
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
F Degenhardt, D Ellinghaus, S Juzenas… - Human molecular …, 2022 - academic.oup.com
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a
deeper analysis of the host genetic contribution to severe COVID-19 is important to improve …
deeper analysis of the host genetic contribution to severe COVID-19 is important to improve …
A year of COVID-19 GWAS results from the GRASP portal reveals potential genetic risk factors
Host genetic variants influence the susceptibility and severity of several infectious diseases,
and the discovery of genetic associations with coronavirus disease 2019 (COVID-19) …
and the discovery of genetic associations with coronavirus disease 2019 (COVID-19) …
Leveraging global multi-ancestry meta-analysis in the study of idiopathic pulmonary fibrosis genetics
The research of rare and devastating orphan diseases, such as idiopathic pulmonary
fibrosis (IPF) has been limited by the rarity of the disease itself. The prognosis is poor—the …
fibrosis (IPF) has been limited by the rarity of the disease itself. The prognosis is poor—the …
Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection
G Barturen, E Carnero-Montoro… - Nature …, 2022 - nature.com
SARS-CoV-2 infection can cause an inflammatory syndrome (COVID-19) leading, in many
cases, to bilateral pneumonia, severe dyspnea, and in~ 5% of these, death. DNA …
cases, to bilateral pneumonia, severe dyspnea, and in~ 5% of these, death. DNA …