Chromatographic separation processes are widely used to isolate and purify value added
products. Most frequently, such separation processes are performed exploiting the principles …

This work presents a comprehensive insight about simulated moving bed (SMB) technology,
from concept to unit operation and process demonstration. A particular relevance is given to …

The simulated moving bed (SMB) technology has evolved significantly since its inception.
The appearance of several variants to conventional SMB has led to better performance in …

Process development, especially in regulated industries, where quality-by-design
approaches have become a prerequisite, is cost intensive and time consuming. A main …

Continuous countercurrent chromatography has been established in industrial operations
for over six decades and in fine chemical and pharmaceutical industry since the 1990s. In …

A simple, yet efficient, two-column simulated moving-bed (2CSMB) process for purifying
adenovirus serotype 5 (Ad5) by size-exclusion chromatography (SEC) is presented and …

A new approach of using computationally cheap surrogate models for efficient optimization
of simulated moving bed (SMB) chromatography is presented. Two different types of …

While normally considered an expensive technology, chromatography has been used for
very large-scale applications for∼ 50 years. Main successes reported in the petrochemical …

This contribution presents a novel model-based methodology for open-loop optimal control
of batch high-pressure liquid chromatographic (HPLC) separation processes. The …

The Parex unit for industrial‐scale purification of p‐xylene was studied through detailed
simulation and the accuracy of the developed model tested against real industrial data …