Mutations in the genes encoding the cytoplasmic and mitochondrial forms of isocitrate
dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently …

Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …

Great strides have been made over the past decade toward comprehensive study of
metabolism. Mass spectrometry (MS) has played a central role by enabling measurement of …

Abstract N 6-methyladenosine (m6A), the most abundant internal modification in eukaryotic
messenger RNAs (mRNAs), has been shown to play critical roles in various normal …

Gliomas are the most common central nervous system tumors. New technologies, including
genetic research and advanced statistical methods, revolutionize the therapeutic approach …

Targeted therapies have come to play an increasingly important role in cancer therapy over
the past two decades. This success has been made possible in large part by technological …

The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …

DNA is vulnerable to damage resulting from endogenous metabolites, environmental and
dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics …

Metabolic reprogramming has become a key focus for both immunologists and cancer
biologists, with exciting advances providing new insights into the mechanisms underlying …

Biochemistry textbooks and cell culture experiments seem to be telling us two different
things about the significance of external glutamine supply for mammalian cell growth and …