CONTEXT: The data describing the urologic extracolonic cancers associated with hereditary
nonpolyposis colorectal cancer (HNPCC) are variable. OBJECTIVE: Provide an update …

I. Introduction: Nonneoplastic Endocrine Hyperplasia (NNEH): The Response of Endocrine
Tissue to Excessive and Sustained Stimulation A SIGNIFICANT part of clinical …

This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

Targeted therapies have yet to have significant impact on the survival of patients with
bladder cancer. In this study, we focused on the urea cycle enzyme argininosuccinate …

To date, two forms of microsatellite instability (MSI) have been described in human cancer.
MSI typical of hereditary nonpolyposis colon cancer (HNPCC), is due to deficient DNA …

Urothelial carcinoma of the renal pelvis and ureter may develop sporadically or as a
manifestation of hereditary nonpolyposis colorectal cancer. The majority of hereditary …

Microsatellites are highly polymorphic, short-tandem repeat sequences dispersed
throughout the genome. Instability of these repeat sequences at multiple genetic loci may …

Defects in the DNA mismatch repair proteins result in microsatellite instability and
malignancy in hereditary non‐polyposis colorectal carcinoma (HNPCC). However, the role …

Patients with Lynch syndrome have an increased risk of urologic malignancies, including
UTUC and likely BUC and PCA. BUC and PCA have a lower penetrance than UTUC for …

Objectives. To investigate the prevalence of the microsatellite instability related to mismatch
repair (MMR) gene defects using a panel of six microsatellite markers, as recommended by …