Survey on the recent advances in 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibition by diketone and triketone derivatives and congeneric compounds …

P Governa, G Bernardini, D Braconi… - Journal of Agricultural …, 2022 - ACS Publications
The serendipitous discovery of the HPPD inhibitors from allelopathic plants opened the way
for searching new and effective herbicidal agents by application of classical hit-to-lead …

The dose makes the poison: nutritional overload determines the life traits of blood-feeding arthropods

M Sterkel, JHM Oliveira, V Bottino-Rojas… - Trends in …, 2017 - cell.com
Vertebrate blood composition is heavily biased towards proteins, and hemoglobin, which is
a hemeprotein, is by far the most abundant protein. Typically, hematophagous insects ingest …

Inhibition of a nutritional endosymbiont by glyphosate abolishes mutualistic benefit on cuticle synthesis in Oryzaephilus surinamensis

JST Kiefer, S Batsukh, E Bauer, B Hirota… - Communications …, 2021 - nature.com
Glyphosate is widely used as a herbicide, but recent studies begin to reveal its detrimental
side effects on animals by targeting the shikimate pathway of associated gut …

4-Hydroxyphenylpyruvate dioxygenase and its inhibition in plants and animals: small molecules as herbicides and agents for the treatment of human inherited …

A Santucci, G Bernardini, D Braconi… - Journal of Medicinal …, 2017 - ACS Publications
This review mainly focuses on the physiological function of 4-hydroxyphenylpyruvate
dioxygenase (HPPD), as well as on the development and application of HPPD inhibitors of …

Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration

M Jhanji, CN Rao, JC Massey, MC Hope III… - Nature …, 2022 - nature.com
Serum tyrosine levels increase during aging, neurocognitive, metabolic, and cardiovascular
disorders. However, calorie restriction (CR) and sleep lower serum tyrosine levels. We …

Tick–pathogen interactions: the metabolic perspective

A Cabezas-Cruz, P Espinosa, P Alberdi… - Trends in …, 2019 - cell.com
The first tick genome published in 2016 provided an invaluable tool for studying the
molecular basis of tick–pathogen interactions. Metabolism is a key element in host …

Comprehensive Quantitative Proteome Analysis of Aedes aegypti Identifies Proteins and Pathways Involved in Wolbachia pipientis and Zika Virus Interference …

M Martins, LFC Ramos, JR Murillo, A Torres… - Frontiers in …, 2021 - frontiersin.org
Zika virus (ZIKV) is a global public health emergency due to its association with
microcephaly, Guillain-Barré syndrome, neuropathy, and myelitis in children and adults. A …

[HTML][HTML] Molecular targets of insecticides and herbicides–Are there useful overlaps?

SO Duke, Z Pan, AG Chittiboyina, DR Swale… - Pesticide Biochemistry …, 2023 - Elsevier
New insecticide modes of action are needed for insecticide resistance management
strategies. The number of molecular targets of commercial herbicides and insecticides are …

Rhodnius prolixus: From classical physiology to modern developmental biology

R Nunes‐da‐Fonseca, M Berni, V Tobias‐Santos… - genesis, 2017 - Wiley Online Library
The hemiptera Rhodnius prolixus is a blood‐feeding insect and a primary vector of
Trypanosoma cruzi, the etiological agent of the Chagas disease. Over the past century …

[HTML][HTML] Putative target sites in synganglion for novel ixodid tick control strategies

J Waldman, GM Klafke, L Tirloni, C Logullo… - Ticks and tick-borne …, 2023 - Elsevier
Acaricide resistance is a global problem that has impacts worldwide. Tick populations with
broad resistance to all commercially available acaricides have been reported. Since …