The growing worldwide challenge of cirrhosis and hepatocellular carcinoma due to
increasing prevalence of excessive alcohol consumption, viral hepatitis, obesity, and the …

The liver is a unique organ for homoeostasis with regenerative capacities. Hepatocytes
possess a remarkable capacity to proliferate upon injury; however, in more severe scenarios …

Despite therapeutic interventions for glioblastoma (GBM), cancer stem cells (CSCs) drive
recurrence. The precise mechanisms underlying CSC resistance, namely inhibition of cell …

The only first-line treatment approved for advanced hepatocellular carcinoma (HCC) is
sorafenib. Since many patients experience drug resistance, the discovery of more effective …

Background and aims Cholangiocarcinoma (CCA) is a form of primary liver cancer with
limited therapeutic options. Recently, cancer stem cells (CSCs) have been proposed as a …

Background: Hepatocellular carcinoma (HCC) is one of the most important sanitary
problems for its prevalence and poor prognosis. To date, no information is available on the …

ABSTRACT SERPINB3 (formerly known as squamous cell carcinoma antigen-1 or SCCA1)
is a member of the family of serine-protease inhibitors. SERPINB3 protects cells from …

Simple Summary This review highlights SerpinB3's multifaceted roles in liver disease, from
fibrosis, carcinogenesis and immune modulation to cell death protection. In different types of …

SerpinB3 has been recently described as an early marker of liver carcinogenesis, but the
potential mechanistic role of this serpin in tumor development is still poorly understood …

SERPINB3 (serpin peptidase inhibitor, clade B (ovalbumin), member 3) - PMC Back to Top
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