We have extended our understanding of the molecular biology that underlies adult
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …

Glioblastoma (GBM) is an incurable brain tumor with a median survival of approximately 15
months despite an aggressive standard of care that includes surgery, chemotherapy, and …

Chimeric antigen receptor (CAR)-T-cell therapy for solid tumors is limited due to
heterogeneous target antigen expression and outgrowth of tumors lacking the antigen …

Glioblastoma multiforme (GBM) is a devastating tumor of the central nervous system,
currently missing an effective treatment. The therapeutic gold standard consists of surgical …

Animal experiments remain essential to understand the fundamental mechanisms
underpinning malignancy and to discover improved methods to prevent, diagnose and treat …

Natural killer (NK) cells are promising effector cells for adjuvant immunotherapy of cancer.
So far, several preclinical studies have shown the feasibility of gene-engineered NK cells …

Successful treatment of brain tumors such as glioblastoma multiforme (GBM) is limited in
large part by the cumulative dose of Radiation Therapy (RT) that can be safely given and the …

GBM (glioblastoma multiforme) is a highly aggressive brain tumour with very poor prognosis
despite multi-modalities of treatment. Furthermore, recent failure of targeted therapy for …

Background: Glioblastoma multiforme is the most aggressive brain tumor with poor
prognosis and an average survival of 1-2 years. Animal models that simulate the features of …

In the human brain, microRNAs (miRNAs) from the microRNA-376 (miR-376) cluster
undergo programmed “seed” sequence modifications by adenosine-to-inosine (A-to-I) …