Peroxisomes carry out various oxidative reactions that are tightly regulated to adapt to the
changing needs of the cell and varying external environments. Accordingly, they are …

An increasing number of industrial bioprocesses capitalize on living cells by using them as
cell factories that convert sugars into chemicals. These processes range from the production …

Natural products account for more than 50% of all small-molecule pharmaceutical agents
currently in clinical use. However, low availability often becomes problematic when a …

The innate immune system is like a double-edged sword: it is absolutely required for host
defense against infection, but when uncontrolled, it can trigger a plethora of inflammatory …

Stochasticity is both exploited and controlled by cells. Although the intrinsic stochasticity
inherent in biochemistry is relatively well understood, cellular variation, or 'noise', is …

Gene expression noise is a universal phenomenon across all life forms. Although beneficial
under certain circumstances, expression noise is generally thought to be deleterious …

The reprogramming of metabolism in response to switching the carbon source from glucose
to non-preferred carbon sources is well-studied for yeast. However, understanding how …

Arabidopsis (Arabidopsis thaliana) high-affinity NITRATE TRANSPORTER2. 1 (NRT2. 1)
plays a dominant role in the uptake of nitrate, the most important nitrogen (N) source for most …

Identification of the underlying molecular mechanisms for a derived phenotype by adaptive
evolution is difficult. Here, we performed a systems-level inquiry into the metabolic changes …

Although several studies have provided important insights into the general principles of
biological networks, the link between network organization and the genome‐scale dynamics …