The permanent cellular constituents of the heart include cardiac fibroblasts, myocytes,
endothelial cells, and vascular smooth muscle cells. Previous studies have demonstrated …

Cardiac fibroblasts account for about 75% of all cardiac cells, but because of their small size
contribute only∼ 10–15% of total cardiac cell volume. They play a crucial role in cardiac …

Cardiac function is determined by the dynamic interaction of various cell types and the
extracellular matrix that composes the heart. This interaction varies with the stage of …

In pathological conditions such as ischemic cardiomyopathy and heart failure, differentiation
of fibroblasts into myofibroblasts may result in myocyte-fibroblast electrical coupling via gap …

Functional intercellular coupling has been demonstrated among networks of cardiac
fibroblasts, as well as between fibroblasts and atrial or ventricular myocytes. In this study, the …

Cardiac dysfunction has an increased prevalence in diseases complicated by liver cirrhosis
such as primary biliary cholangitis and primary sclerosing cholangitis. This observation has …

Although cardiac action potential (AP) generation and propagation have traditionally been
attributed exclusively to cardiomyocytes (CM), other cell types in the heart are also capable …

Cardiac fibrosis occurs in a number of cardiovascular diseases associated with a high
incidence of arrhythmias. A critical event in the development of fibrosis is the transformation …

Cardiac function is determined by the coordinated and dynamic interaction of several cell
types together with components of the extracellular matrix (ECM). This interaction is …

Introduction: The genesis of atrial fibrillation (AF) and success of AF ablation therapy have
been strongly linked with atrial fibrosis. Increasing evidence suggests that patient-specific …