Role of neuroinflammation in neurodegeneration development
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
The blood-brain barrier in aging and neurodegeneration
The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an
exquisite control of exchange of compounds between the blood and the brain parenchyma …
exquisite control of exchange of compounds between the blood and the brain parenchyma …
A single-cell atlas of the normal and malformed human brain vasculature
Cerebrovascular diseases are a leading cause of death and neurologic disability. Further
understanding of disease mechanisms and therapeutic strategies requires a deeper …
understanding of disease mechanisms and therapeutic strategies requires a deeper …
Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state
S Smajić, CA Prada-Medina, Z Landoulsi, J Ghelfi… - Brain, 2022 - academic.oup.com
Idiopathic Parkinson's disease is characterized by a progressive loss of dopaminergic
neurons, but the exact disease aetiology remains largely unknown. To date, Parkinson's …
neurons, but the exact disease aetiology remains largely unknown. To date, Parkinson's …
Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function
The ε4 allele of the apolipoprotein E (APOE) gene, a genetic risk factor for Alzheimer's
disease, is abundantly expressed in both the brain and periphery. Here, we present …
disease, is abundantly expressed in both the brain and periphery. Here, we present …
A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity
The blood–brain barrier is playing a critical role in controlling the influx and efflux of
biological substances essential for the brain's metabolic activity as well as neuronal function …
biological substances essential for the brain's metabolic activity as well as neuronal function …
Blood-brain barrier dysfunction amplifies the development of neuroinflammation: understanding of cellular events in brain microvascular endothelial cells for …
F Takata, S Nakagawa, J Matsumoto… - Frontiers in cellular …, 2021 - frontiersin.org
Neuroinflammation is involved in the onset or progression of various neurodegenerative
diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage …
diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage …
Drug delivery to the central nervous system
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …
development remains challenging, with high costs, long pathways to clinical use and high …
APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline
Vascular contributions to dementia and Alzheimer's disease are increasingly recognized,,,,–.
Recent studies have suggested that breakdown of the blood–brain barrier (BBB) is an early …
Recent studies have suggested that breakdown of the blood–brain barrier (BBB) is an early …
Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …