Background Glucagon-like peptide-1 receptor (GLP-1R) agonists are approved for the
treatment of type 2 diabetes and obesity and elicit robust improvements in glycemic control …

Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

Infection-related diabetes can arise as a result of virus-associated β-cell destruction. Clinical
data suggest that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Human pluripotent stem cells differentiated to insulin-secreting β cells (SC-β cells) in islet
organoids could provide an unlimited cell source for diabetes cell replacement therapy …

The mechanisms that specify and stabilize cell subtypes remain poorly understood. Here,
we identify two major subtypes of pancreatic β cells based on histone mark heterogeneity (β …

The increasing availability of large-scale single-cell atlases has enabled the detailed
description of cell states. In parallel, advances in deep learning allow rapid analysis of newly …

Abstract Glucagon-like peptide-1 (GLP-1) receptor agonists are established pharmaceutical
therapies for the treatment of type 2 diabetes and obesity. They mimic the action of GLP-1 to …

Recent advances in multiplexed single‐cell transcriptomics experiments facilitate the high‐
throughput study of drug and genetic perturbations. However, an exhaustive exploration of …

Background Single-cell RNA sequencing (scRNA-seq) provides valuable insights into
human islet cell types and their corresponding stable gene expression profiles. However …

The pancreatic islets are composed of discrete hormone-producing cells that orchestrate
systemic glucose homeostasis. Here we identify subsets of beta cells using a single-cell …