Biomechanical properties of native and tissue engineered heart valve constructs
Due to the increasing number of heart valve diseases, there is an urgent clinical need for off-
the-shelf tissue engineered heart valves. While significant progress has been made toward …
the-shelf tissue engineered heart valves. While significant progress has been made toward …
Hemodynamics and mechanobiology of aortic valve inflammation and calcification
K Balachandran, P Sucosky… - International journal of …, 2011 - Wiley Online Library
Cardiac valves function in a mechanically complex environment, opening and closing close
to a billion times during the average human lifetime, experiencing transvalvular pressures …
to a billion times during the average human lifetime, experiencing transvalvular pressures …
Mechanical considerations for polymeric heart valve development: Biomechanics, materials, design and manufacturing
The native human heart valve leaflet contains a layered microstructure comprising a
hierarchical arrangement of collagen, elastin, proteoglycans and various cell types. Here …
hierarchical arrangement of collagen, elastin, proteoglycans and various cell types. Here …
The living aortic valve: From molecules to function
The aortic valve lies in a unique hemodynamic environment, one characterized by a range
of stresses (shear stress, bending forces, loading forces and strain) that vary in intensity and …
of stresses (shear stress, bending forces, loading forces and strain) that vary in intensity and …
Computational comparison of regional stress and deformation characteristics in tricuspid and bicuspid aortic valve leaflets
K Cao, P Sucosky - International journal for numerical methods …, 2017 - Wiley Online Library
The bicuspid aortic valve (BAV) is the most common congenital valvular defect and a major
risk factor for secondary calcific aortic valve disease. While hemodynamics is presumed to …
risk factor for secondary calcific aortic valve disease. While hemodynamics is presumed to …
Cardiac valve scaffold design: Implications of material properties and geometric configuration on performance and mechanics
Abstract Development of tissue engineered scaffolds for cardiac valve replacement is
nearing clinical translation. While much work has been done to characterize mechanical …
nearing clinical translation. While much work has been done to characterize mechanical …
Cell-matrix mechanics and pattern formation in inflammatory cardiovascular calcification
Calcific diseases of the cardiovascular system, such as atherosclerotic calcification and
calcific aortic valve disease, are widespread and clinically significant, causing substantial …
calcific aortic valve disease, are widespread and clinically significant, causing substantial …
Fully coupled fluid–structure interaction model of congenital bicuspid aortic valves: effect of asymmetry on hemodynamics
G Marom, HS Kim, M Rosenfeld, E Raanani… - Medical & biological …, 2013 - Springer
A bicuspid aortic valve (BAV) is a congenital cardiac disorder where the valve consists of
only two cusps instead of three, as in a normal tricuspid valve (TAV). Although 97% of BAVs …
only two cusps instead of three, as in a normal tricuspid valve (TAV). Although 97% of BAVs …
Heart Valve Biomechanics: The Frontiers of Modeling Modalities and the Expansive Capabilities of Ex Vivo Heart Simulation
MH Park, Y Zhu, AM Imbrie-Moore, H Wang… - Frontiers in …, 2021 - frontiersin.org
The field of heart valve biomechanics is a rapidly expanding, highly clinically relevant area
of research. While most valvular pathologies are rooted in biomechanical changes, the …
of research. While most valvular pathologies are rooted in biomechanical changes, the …
Spatiotemporal complexity of the aortic sinus vortex
The aortic sinus vortex is a classical flow structure of significant importance to aortic valve
dynamics and the initiation and progression of calcific aortic valve disease. We characterize …
dynamics and the initiation and progression of calcific aortic valve disease. We characterize …