Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics
that neutralize TNF are among the most successful drugs for the treatment of chronic …

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell
death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain …

Various forms of cell death have been identified over the last decades with each relying on a
different subset of proteins for the activation and execution of their respective pathway (s). In …

The aspartate-specific cysteine protease caspase-8 suppresses necroptotic cell death
mediated by RIPK3 and MLKL. Indeed, mice that lack caspase-8 die in a RIPK3-and MLKL …

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal
inflammatory response, RIPK1 is regulated post-translationally by well-characterized …

Cell death and inflammation are closely linked arms of the innate immune response to
combat infection and tissue malfunction. Recent advancements in our understanding of the …

Tumor necrosis factor alpha (TNF; TNFα) is a critical regulator of immune responses in
healthy organisms and in disease. TNF is involved in the development and proper …

Activation of RIPK1 controls TNF-mediated apoptosis, necroptosis and inflammatory
pathways. Cleavage of human and mouse RIPK1 after residues D324 and D325 …

Tumor necrosis factor (TNF) plays a central role in orchestrating mammalian inflammatory
responses. It promotes inflammation either directly by inducing inflammatory gene …