Oxidative stress-induced damage to the retinal pigment epithelium (RPE) is considered to
be a key factor in age-related macular degeneration (AMD) pathology. RPE cells are …

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
the developed world. The identification of the central role of vascular endothelial growth …

The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells,
strategically situated between the photoreceptors and the choroid, is the primary caretaker of …

Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the
elderly, with limited therapeutic options. Here we report on a study of> 12 million variants …

In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G)
complement plays a primary role in disease pathogenesis. Herein we report the outcome of …

Inherited and age-related retinal degeneration is the hallmark of a large group of
heterogeneous diseases and is the main cause of untreatable blindness today. Genetic …

Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
adults over 50 years old. Genetic, epidemiological, and molecular studies are beginning to …

Tissue and cell-type identity lie at the core of human physiology and disease. Understanding
the genetic underpinnings of complex tissues and individual cell lineages is crucial for …

Polypoidal choroidal vasculopathy (PCV) is an age-related macular degeneration (AMD)
subtype and is seen particularly in Asians. Previous studies have suggested disparity in …