New opportunities and old challenges in the clinical translation of nanotheranostics
Nanoparticle-based systems imbued with both diagnostic and therapeutic functions, known
as nanotheranostics, have enabled remarkable progress in guiding focal therapy, inducing …
as nanotheranostics, have enabled remarkable progress in guiding focal therapy, inducing …
Supramolecular cancer nanotheranostics
Among the many challenges in medicine, the treatment and cure of cancer remains an
outstanding goal given the complexity and diversity of the disease. Nanotheranostics, the …
outstanding goal given the complexity and diversity of the disease. Nanotheranostics, the …
Polymer–drug conjugate therapeutics: advances, insights and prospects
Polymer–drug conjugates have long been a mainstay of the drug delivery field, with several
conjugates successfully translated into clinical practice. The conjugation of therapeutic …
conjugates successfully translated into clinical practice. The conjugation of therapeutic …
The expanding role of prodrugs in contemporary drug design and development
J Rautio, NA Meanwell, L Di… - Nature reviews drug …, 2018 - nature.com
Prodrugs are molecules with little or no pharmacological activity that are converted to the
active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two …
active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two …
Rethinking cancer nanotheranostics
Advances in nanoparticle synthesis and engineering have produced nanoscale agents
affording both therapeutic and diagnostic functions that are often referred to by the …
affording both therapeutic and diagnostic functions that are often referred to by the …
Targeted drug delivery with polymers and magnetic nanoparticles: covalent and noncovalent approaches, release control, and clinical studies
K Ulbrich, K Hola, V Subr, A Bakandritsos… - Chemical …, 2016 - ACS Publications
Targeted delivery combined with controlled drug release has a pivotal role in the future of
personalized medicine. This review covers the principles, advantages, and drawbacks of …
personalized medicine. This review covers the principles, advantages, and drawbacks of …
pH-responsive self-healing injectable hydrogel based on N-carboxyethyl chitosan for hepatocellular carcinoma therapy
Injectable hydrogels with pH-responsiveness and self-healing ability have great potential for
anti-cancer drug delivery. Herein, we developed a series of polysaccharide-based self …
anti-cancer drug delivery. Herein, we developed a series of polysaccharide-based self …
Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy
E Pérez-Herrero, A Fernández-Medarde - European journal of …, 2015 - Elsevier
Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases.
It is characterized by uncontrolled cell proliferation and an absence of cell death that, except …
It is characterized by uncontrolled cell proliferation and an absence of cell death that, except …
Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications
A Wicki, D Witzigmann, V Balasubramanian… - Journal of controlled …, 2015 - Elsevier
Cancer is a leading cause of death worldwide. Currently available therapies are inadequate
and spur demand for improved technologies. Rapid growth in nanotechnology towards the …
and spur demand for improved technologies. Rapid growth in nanotechnology towards the …
Carrier-free nanomedicines for cancer treatment
LH Liu, XZ Zhang - Progress in Materials Science, 2022 - Elsevier
The last decade witnessed the great advances in the development of nanomedicines. As a
kind of attractive nanomedicine, carrier-free nanomedicines received extensive …
kind of attractive nanomedicine, carrier-free nanomedicines received extensive …