Chronic pain is associated with abnormal excitability of the somatosensory system and
remains poorly treated in the clinic. Potassium (K+) channels are crucial determinants of …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Sleep quality declines with age; however, the underlying mechanisms remain elusive. We
found that hyperexcitable hypocretin/orexin (Hcrt/OX) neurons drive sleep fragmentation …

Pain models in animals have shown low predictivity for analgesic efficacy in humans, and
clinical studies are often very confounded, blurring the evaluation. Human experimental pain …

Neuropathic pain is a debilitating clinical problem and difficult to treat. Nerve injury causes a
long-lasting reduction in K+ channel expression in the dorsal root ganglion (DRG), but little …

Electrical excitation of peripheral somatosensory nerves is a first step in generation of most
pain signals in mammalian nervous system. Such excitation is controlled by an intricate set …

Sensory abnormalities generated by nerve injury, peripheral neuropathy or disease are
often expressed as neuropathic pain. This type of pain is frequently resistant to therapeutic …

Approximately 50 million people have epilepsy, making it the most common chronic and
severe neurological disease worldwide, with increased risk of mortality and psychological …

Voltage‐gated potassium channels (Kv) are important regulators of neuronal excitability for
its role of regulating resting membrane potential and repolarization. Recent studies show …

Bone cancer pain has a strong impact on the quality of life of patients, but is difficult to treat.
Better understanding of the pathogenic mechanisms underlying bone cancer pain will likely …