Genomic analyses in cancer have been enormously impactful, leading to the identification of
driver mutations and development of targeted therapies. But the functions of the vast majority …

Recent advances in single-cell biotechnologies have resulted in high-dimensional datasets
with increased complexity, making feature selection an essential technique for single-cell …

Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …

Most genetic variations associated with human complex traits are located in non-coding
genomic regions. Therefore, understanding the genotype-to-phenotype axis requires a …

Cancer progression is driven by both somatic copy number aberrations (CNAs) and
chromatin remodeling, yet little is known about the interplay between these two classes of …

Single-cell sequencing technology has enabled the discovery and characterization of
subpopulations of immune cells with unique functions, which is critical for revealing immune …

The Fontan operation is the current standard of care for single-ventricle congenital heart
disease. Individuals with a Fontan circulation (FC) exhibit central venous hypertension and …

As part of the Human Cell Atlas Initiative, our goal is to generate single-cell transcriptomics
(single-cell RNA sequencing [scRNA-seq], 86,708 cells) and regulatory (single-cell assay on …

Acute myeloid leukemia (AML) is a heterogeneous disease characterized by high rate of
therapy resistance. Since the cell of origin can impact response to therapy, it is crucial to …

Single-cell ATAC-seq sequencing data (scATAC-seq) has been widely used to investigate
chromatin accessibility on the single-cell level. One important application of scATAC-seq …