Comorbidities are a hallmark of stroke that both increase the incidence of stroke and worsen
outcome. Hypertension is prevalent in the stroke population and the most important …

The incidence of age-related dementia is increasing as the world population ages and due
to lack of effective treatments for dementia. Vascular contributions to cognitive impairment …

Maintenance of brain function depends on a constant blood supply. Deficits in cerebral
blood flow are linked to cognitive decline, and they have detrimental effects on the outcome …

Background and Purpose—Collaterals sustain the penumbra before recanalization and
offset infarct growth, yet the influence of baseline collateral flow on recanalization after …

This e-book will review special features of the cerebral circulation and how they contribute to
the physiology of the brain. It describes structural and functional properties of the cerebral …

Despite ongoing advances in stroke imaging and treatment, ischemic and hemorrhagic
stroke continue to debilitate patients with devastating outcomes at both the personal and …

Faraci, Frank M., and Donald D. Heistad. Regulation of the Cerebral Circulation: Role of
Endothelium and Potassium Channels. Physiol. Rev. 78: 53–97, 1998.—Several new …

Background and Purpose—Collaterals sustain the ischemic penumbra to limit growth of the
infarct core before revascularization, yet the impact of baseline collateral flow on …

High blood pressure (BP) is common after ischemic stroke and associated with a poor
functional outcome and increased mortality. The conundrum then arises on whether to lower …

The myogenic response of small arteries and arterioles has been shown to contribute
significantly to autoregulation in different vascular beds. It is characterized by a constriction …