This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Potassium channels importantly contribute to the regulation of vascular smooth muscle
(VSM) contraction and growth. They are the dominant ion conductance of the VSM cell …

Adequate 24-h BP control presently offers the most feasible intervention for reducing
glomerular BP transmission and improving suboptimal outcomes in CKD. Investigations …

Inward rectifier potassium channels (Kir channels) exist in a variety of cells and are involved
in maintaining resting membrane potential and signal transduction in most cells, as well as …

The control of renal vascular tone is important for the regulation of salt and water balance,
blood pressure and the protection against damaging elevated glomerular pressure. The K+ …

Resistant hypertension is defined as high blood pressure that remains uncontrolled despite
treatment with at least three antihypertensive drugs at adequate doses. Resistant …

K+ conductance is a major determinant of membrane potential (V m) in vascular smooth
muscle (VSMC) and endothelial cells (EC). The vascular tone is controlled by V m through …

This review is focused on the effects of obesity on function and expression of potassium (K)
channels in the vasculature. Five families of K channels have been identified in the vascular …