Concept of hybrid drugs and recent advancements in anticancer hybrids
Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …
Mitocans revisited: mitochondrial targeting as efficient anti-cancer therapy
Mitochondria are essential cellular organelles, controlling multiple signalling pathways
critical for cell survival and cell death. Increasing evidence suggests that mitochondrial …
critical for cell survival and cell death. Increasing evidence suggests that mitochondrial …
Targeting SARS-CoV-2 spike protein of COVID-19 with naturally occurring phytochemicals: an in silico study for drug development
Spike glycoprotein, a class I fusion protein harboring the surface of SARS-CoV-2 (SARS-
CoV-2S), plays a seminal role in the viral infection starting from recognition of the host cell …
CoV-2S), plays a seminal role in the viral infection starting from recognition of the host cell …
LncRNA LINC00662 promotes colon cancer tumor growth and metastasis by competitively binding with miR-340-5p to regulate CLDN8/IL22 co-expression and …
B Cheng, A Rong, Q Zhou, W Li - Journal of Experimental & Clinical …, 2020 - Springer
Background LncRNA LINC00662 is closely related to the occurrence and development of
cancer. This study aims to explore the effect of LINC00662 on colon cancer tumor growth …
cancer. This study aims to explore the effect of LINC00662 on colon cancer tumor growth …
Current status of carbazole hybrids as anticancer agents
G Wang, S Sun, H Guo - European Journal of Medicinal Chemistry, 2022 - Elsevier
The drug resistance and low specificity of current available chemotherapeutics to cancer
cells are the main reasons responsible for the failure of cancer chemotherapy and remain …
cells are the main reasons responsible for the failure of cancer chemotherapy and remain …
Rational optimization of 1, 2, 3-triazole-tailored carbazoles as prospective antibacterial alternatives with significant in vivo control efficiency and unique mode of action
X Huang, HW Liu, ZQ Long, ZX Li, JJ Zhu… - Journal of Agricultural …, 2021 - ACS Publications
Plant bacterial diseases can potentially damage agricultural products around the world, and
few effective bactericides can manage these infections. Herein, to sequentially explore …
few effective bactericides can manage these infections. Herein, to sequentially explore …
[HTML][HTML] Anthelmintics for drug repurposing: Opportunities and challenges
SE Alavi, HE Shahmabadi - Saudi Pharmaceutical Journal, 2021 - Elsevier
Drug repositioning is defined as a process to identify a new application for drugs. This
approach is critical as it takes advantage of well-known pharmacokinetics …
approach is critical as it takes advantage of well-known pharmacokinetics …
Have molecular hybrids delivered effective anti-cancer treatments and what should future drug discovery focus on?
Shalini, V Kumar - Expert Opinion on Drug Discovery, 2021 - Taylor & Francis
Introduction Cancer continues to be a big threat and its treatment is a huge challenge
among the medical fraternity. Conventional anti-cancer agents are losing their efficiency …
among the medical fraternity. Conventional anti-cancer agents are losing their efficiency …
Emerging importance of tyrosine kinase inhibitors against cancer: quo vadis to cure?
GLOBOCAN 2020 estimated more than 19.3 million new cases, and about 10 million
patients were deceased from cancer in 2020. Clinical manifestations showed that several …
patients were deceased from cancer in 2020. Clinical manifestations showed that several …
Targeting virus–host interaction by novel pyrimidine derivative: an in silico approach towards discovery of potential drug against COVID-19
The entire human population over the globe is currently facing appalling conditions due to
the spread of infection from coronavirus disease-2019 (COVID-19). The spike glycoprotein …
the spread of infection from coronavirus disease-2019 (COVID-19). The spike glycoprotein …