This review is a summary of factors affecting the drug pharmacokinetics (PK) of dogs versus
humans. Identifying these interspecies differences can facilitate canine-human PK …

Although novel agents hold great promise for the treatment of animal neoplasia, there may
be room for significant improvement in the use of currently available agents. These …

Background Liver x receptor α (LXRα) is a ligand-activated transcription factor belonging to
the nuclear receptor superfamily. Oxysterols (endogenous oxidized cholesterol derivatives) …

Selection of surrogate peptides plays a major role to achieve reproducible and accurate
quantification of desired proteins in targeted proteomics. Currently, available peptide …

Co-occurrences of peptides and chemical components are usually observed in complicated
matrices. Notably, those traditional Chinese medicine prescriptions (TCMPs) contain both …

The dog is an important species used in preclinical studies in support of human drug product
development. Likewise, because of the many active pharmaceutical ingredients with …

The oral delivery of drugs is the most popular route of administration for patients. However,
thymopentin (TP5) is only available in the market in forms for parenteral administration as an …

1 Hintergrund und Ziele Die ATP-binding cassette (ABC) Transporter stellen eine der
größten Gruppen unter den Transmembranproteinen dar. Sie ermöglichen unter Verbrauch …