Background Influenza vaccine effectiveness (VE) can vary by type and subtype. Over the
past decade, the test-negative design has emerged as a valid method for estimation of VE …

Vaccine-preventable diseases are a significant cause of morbidity and mortality. As new
vaccines are proving to be effective and as the incidence of some infections decreases …

Background. Circulating A/H3N2 influenza viruses drifted significantly after strain selection
for the 2014–2015 vaccines. Also in 2014–2015, the Advisory Committee on Immunization …

Background Improved influenza vaccines are needed to control seasonal epidemics. This
trial compared the protective efficacy in older adults of a quadrivalent, recombinant influenza …

Background: There is a continued need for strategies to prevent influenza. While
cetylpyridinium chloride (CPC), a broad-spectrum antimicrobial agent, has an extensive …

ABSTRACT Since 2003 (US) and 2012 (Europe) the live attenuated influenza vaccine
(LAIV) has been used as an alternative to the traditional inactivated influenza vaccines (IIV) …

Background. The predominant strain during the 2013–2014 influenza season was 2009
pandemic influenza A (H1N1) virus (A [H1N1] pdm09). This vaccine-component has …

ABSTRACT VX-787 is a novel inhibitor of influenza virus replication that blocks the PB2 cap-
snatching activity of the influenza viral polymerase complex. Viral genetics and X-ray …

Abstract Background. During the 2014–2015 US influenza season, expanded genetic
characterization of circulating influenza A (H3N2) viruses was used to assess the impact of …

Background Current prevention options for upper respiratory infections (URIs) are not
optimal. We conducted a randomized, double-blinded, placebo-controlled pilot clinical trial …