Serotonin and brain function: a tale of two receptors

RL Carhart-Harris, DJ Nutt - Journal of psychopharmacology, 2017 - journals.sagepub.com
Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

Reviewing the potential of psychedelics for the treatment of PTSD

E Krediet, T Bostoen, J Breeksema… - International Journal …, 2020 - academic.oup.com
There are few medications with demonstrated efficacy for the treatment of posttraumatic
stress disorder (PTSD). Treatment guidelines have unequivocally designated psychotherapy …

[HTML][HTML] MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial

JM Mitchell, M Ot'alora G, B van der Kolk, S Shannon… - Nature Medicine, 2023 - nature.com
This multi-site, randomized, double-blind, confirmatory phase 3 study evaluated the efficacy
and safety of 3, 4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) versus …

MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study

JM Mitchell, M Bogenschutz, A Lilienstein, C Harrison… - Focus, 2023 - Am Psychiatric Assoc
Post-traumatic stress disorder (PTSD) presents a major public health problem for which
currently available treatments are modestly effective. We report the findings of a randomized …

[HTML][HTML] Distinct acute effects of LSD, MDMA, and d-amphetamine in healthy subjects

F Holze, P Vizeli, F Müller, L Ley, R Duerig… - …, 2020 - nature.com
Lysergic acid diethylamide (LSD) is a classic psychedelic, 3, 4-
methylenedioxymethamphetamine (MDMA) is an empathogen, and d-amphetamine is a …

Acute effects of lysergic acid diethylamide in healthy subjects

Y Schmid, F Enzler, P Gasser, E Grouzmann… - Biological …, 2015 - Elsevier
Background After no research in humans for> 40 years, there is renewed interest in using
lysergic acid diethylamide (LSD) in clinical psychiatric research and practice. There are no …

[HTML][HTML] MDMA-assisted psychotherapy for treatment of anxiety and other psychological distress related to life-threatening illnesses: a randomized pilot study

PE Wolfson, J Andries, AA Feduccia, L Jerome… - Scientific reports, 2020 - nature.com
The success of modern medicine creates a growing population of those suffering from life-
threatening illnesses (LTI) who often experience anxiety, depression, and existential …

[HTML][HTML] Breakthrough for trauma treatment: safety and efficacy of MDMA-assisted psychotherapy compared to paroxetine and sertraline

AA Feduccia, L Jerome, B Yazar-Klosinski… - Frontiers in …, 2019 - frontiersin.org
Unsuccessfully treated posttraumatic stress disorder (PTSD) is a serious and life-threatening
disorder. Two medications, paroxetine hydrochloride and sertraline hydrochloride, are …

[HTML][HTML] LSD acutely impairs fear recognition and enhances emotional empathy and sociality

PC Dolder, Y Schmid, F Müller, S Borgwardt… - …, 2016 - nature.com
Lysergic acid diethylamide (LSD) is used recreationally and has been evaluated as an
adjunct to psychotherapy to treat anxiety in patients with life-threatening illness. LSD is well …

3, 4-Methylenedioxymethamphetamine-assisted psychotherapy for treatment of chronic posttraumatic stress disorder: a randomized phase 2 controlled trial

M Ot'alora G, J Grigsby, B Poulter… - Journal of …, 2018 - journals.sagepub.com
Background: Posttraumatic stress disorder often does not resolve after conventional
psychotherapies or pharmacotherapies. Pilot studies have reported that 3, 4 …