This review explored the role of mitochondria in retinal ganglion cells (RGCs), which are
essential for visual processing. Mitochondrial dysfunction is a key factor in the pathogenesis …

Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism
and functional mitochondria to keep ATP levels in physiological range. Imbalances in …

Mitochondrial dysfunction in astrocytes has been implicated in the development of various
neurological disorders. Mitophagy, mitochondrial autophagy, is required for proper …

AAV gene therapy for ocular disease has become a reality with the market authorisation of
LuxturnaTM for RPE65-linked inherited retinal degenerations and many AAV gene therapies …

Tropical ataxic neuropathy (TAN) is characterised by ataxic polyneuropathy, degeneration of
the posterior columns and pyramidal tracts, optic atrophy, and sensorineural hearing loss. It …

Background Biallelic variants in RTN4IP1 are a well-established cause of syndromic and
nonsyndromic early-onset autosomal recessive optic neuropathy. They have more recently …

Autosomal Dominant Optic Atrophy (ADOA) is a rare neurodegenerative condition,
characterized by the bilateral loss of vision due to the degeneration of retinal ganglion cells …

Mitochondria play a central role in cellular metabolism in almost all eukaryotes, and at the
core of this function is the oxidative phosphorylation system. Complex I serves as the entry …