[HTML][HTML] Affective neuroscience of loneliness: potential mechanisms underlying the association between perceived social isolation, health, and well-being

AJ Finley, SM Schaefer - Journal of psychiatry and brain science, 2022 - ncbi.nlm.nih.gov
Loneliness, or the subjective feeling of social isolation, is an important social determinant of
health. Loneliness is associated with poor physical health, including higher rates of …

Social health and subsequent cognitive functioning in people aged 50 years and older: examining the mediating roles of depressive symptoms and inflammatory …

J Stafford, S Dekhtyar, AK Welmer… - The Lancet Healthy …, 2024 - thelancet.com
Background Social health markers, including marital status, contact frequency, network size,
and social support, have been shown to be associated with cognition. However, the …

Contributions of loneliness to cognitive impairment and dementia in older adults are independent of other risk factors and Alzheimer's pathology: a narrative review

BS Oken, J Kaplan, D Klee… - Frontiers in Human …, 2024 - frontiersin.org
Loneliness significantly contributes to cognitive impairment and dementia in older adults.
Loneliness is a distressing feeling resulting from a perceived lack of social connection (ie, a …

[HTML][HTML] Assessing the Impact and Cost-Effectiveness of Exposome Interventions on Alzheimer's Disease: A Review of Agent-Based Modeling and Other Data Science …

SH Liu, ES Weber, KE Manz, KJ McCarthy, Y Chen… - Genes, 2024 - mdpi.com
Background: The exposome (eg, totality of environmental exposures) and its role in
Alzheimer's Disease and Alzheimer's Disease and Related Dementias (AD/ADRD) are …

Associations between longitudinal loneliness, DNA methylation age acceleration, and cognitive functioning

M Lynch, T Em Arpawong… - The Journals of …, 2023 - academic.oup.com
Objectives Loneliness may influence aging biomarkers related to cognitive functioning, for
example, through accelerated DNA methylation (DNAm) aging. Methods In the present …

[HTML][HTML] Association of Loneliness with Functional and Cognitive Status in Minor and Major Neurocognitive Disorders

MC Moretti, I Bonfitto, L Nieddu, I Leccisotti, S Dimalta… - Life, 2024 - mdpi.com
Background: Neurocognitive disorders (NCDs) have a variable decline in cognitive function,
while loneliness was associated with cognitive impairment and increased dementia risk. In …

[HTML][HTML] Social isolation, loneliness, and their joint effects on cognitive decline and incident Alzheimer's disease: Findings from the Chicago health and aging project

TKS Ng, T Beck, KR Dennis, P Desai, K Krueger… - The Journal of …, 2025 - Elsevier
Background There has been contradictory evidence on the prospective associations
between social isolation/loneliness (SI/L) and cognitive decline (CD). There is also a scarcity …

Loneliness Gets Under the Skin: A Scoping Review Exploring the Link Between Loneliness and Biological Measures of Inflammation

B Kim, M Weibel, J McDaniel - Western Journal of Nursing …, 2024 - journals.sagepub.com
Background: Research suggests that systemic inflammation may link loneliness to adverse
health outcomes, yet there is a gap in comprehensively reviewing recent evidence on the …

Dyadic loneliness and kidney functioning among older couples in Europe

JE Stokes, L Jessee, M Luchetti… - Journal of Global …, 2024 - bristoluniversitypressdigital.com
Loneliness is a growing public health concern among the ageing population. Increasingly,
scholars have recognised that even married and partnered persons experience loneliness …

Life‐Space Mobility Is Related to Loneliness Among Living‐Alone Older Adults: Longitudinal Analysis With Motion Sensor Data

K Yu, CY Wu, LL Barnes, LC Silbert, Z Beattie… - Journal of the … - Wiley Online Library
Background Life‐space mobility can be a behavioral indicator of loneliness. This study
examined the association between life‐space mobility measured with motion sensors and …