The innate immune system is the first line of defense against pathogens, which is initiated by
the recognition of pathogen-associated molecular patterns (PAMPs) and endogenous …

Annexin A2 (AnxA2) is a multifunctional calcium2+ (Ca2+) and phospholipid-binding protein
that is expressed in a wide spectrum of cells, including those participating in the …

Background: Cardiovascular risk in diabetes remains elevated despite glucose-lowering
therapies. We hypothesized that hyperglycemia induces trained immunity in macrophages …

Recent evidence indicates synaptic dysfunction as an early mechanism affected in
neuroinflammatory diseases, such as multiple sclerosis, which are characterized by chronic …

Extracellular ATP is among molecules promoting microglia activation and inducing the
release of extracellular vesicles (EVs), which are potent mediators of intercellular …

Lymph nodes (LNs) are critical sites for shaping tissue-specific adaptive immunity. However,
the impact of LN sharing between multiple organs on such tailoring is less understood. Here …

Abstract Background Annexin A2 (AnxA2) is a multifunctional protein involved in
endocytosis, exocytosis, membrane domain organisation, actin remodelling, signal …

Rapid and accurate diagnosis of sepsis remains clinically challenging. The lack of specific
biomarkers that can differentiate sepsis from non-infectious systemic inflammatory diseases …

Abstract Annexin A2 (ANXA2) is widely used as a marker in a variety of tumors. By
regulating multiple signal pathways, ANXA2 promotes the epithelial‐mesenchymal …

Routine manipulation of the mouse genome has become a landmark in biomedical
research. Traits that are only associated with advanced developmental stages can now be …