Partially-reduced forms of dioxygen or “oxy-radicals”(superoxide, O 2⨪ HO 2·; hydrogen
peroxide H 2 O 2; hydroxyl radical· OH) and oxidants of comparable reactivity are implicated …

Over the past 15 to 20 years much has been learned about genetic (hereditary, primary,
idiopathic) hemochromatosis (GH). Confirmation that the disease is an inherited disorder of …

Background The mechanisms responsible for disturbed iron homoeostasis in hereditary
haemochromatosis are poorly understood. However, results of some studies indicate a link …

The role of the measurement of hepatic iron in the diagnosis of genetic hemochromatosis
was studied, with particular reference to the differentiation of early hemochromatosis from …

The involvement of free radical reactions in the pathogenesis of liver injury has been
investigated for many years in a few defined experimental systems using carbon …

Peroxidative decomposition of cellular membrane lipids is a postulated mechanism of
hepatocellular injury in parenchymal iron overload. In the present study, we looked for direct …

Although the complex processes which accompany oxidative stress result in damage to
many cell components, peroxidative decomposition of membrane lipids and the associated …

In hepatic iron overload, iron-catalyzed lipid peroxidation has been implicated in the
mechanisms of hepatocellular injury. Lipid peroxidation may produce reactive aldehydes …

The advent of the genetics era has profoundly changed the way we look at iron related
diseases, particularly hemochromatosis. New discoveries have challenged historical …

The risk of hepatocellular carcinoma (HCC) and other internal malignancies was examined
in patients with genetic hemochromatosis (GH) by following 208 patients from the time of …