Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection
P Fuentes-Prior - Journal of Biological Chemistry, 2021 - ASBMB
The ongoing COVID-19 pandemic has already caused over a million deaths worldwide, and
this death toll will be much higher before effective treatments and vaccines are available …
this death toll will be much higher before effective treatments and vaccines are available …
Cell surface–anchored serine proteases in cancer progression and metastasis
CE Martin, K List - Cancer and Metastasis Reviews, 2019 - Springer
Over the last two decades, a novel subgroup of serine proteases, the cell surface–anchored
serine proteases, has emerged as an important component of the human degradome, and …
serine proteases, has emerged as an important component of the human degradome, and …
[HTML][HTML] An MMP-9 exclusive neutralizing antibody attenuates blood-brain barrier breakdown in mice with stroke and reduces stroke patient-derived MMP-9 activity
Y Ji, Q Gao, Y Ma, F Wang, X Tan, D Song… - Pharmacological …, 2023 - Elsevier
Rapid upregulation of matrix metalloproteinase 9 (MMP-9) leads to blood-brain barrier
(BBB) breakdown following stroke, but no MMP-9 inhibitors have been approved in clinic …
(BBB) breakdown following stroke, but no MMP-9 inhibitors have been approved in clinic …
Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis
J Chavarria-Smith, CPC Chiu, JK Jackman… - Science Translational …, 2022 - science.org
The epidermis is a barrier that prevents water loss while keeping harmful substances from
penetrating the host. The impermeable cornified layer of the stratum corneum is maintained …
penetrating the host. The impermeable cornified layer of the stratum corneum is maintained …
Inhibition of plasma kallikrein by a highly specific active site blocking antibody
JA Kenniston, RR Faucette, D Martik… - Journal of Biological …, 2014 - ASBMB
Plasma kallikrein (pKal) proteolytically cleaves high molecular weight kininogen to generate
the potent vasodilator and the pro-inflammatory peptide, bradykinin. pKal activity is tightly …
the potent vasodilator and the pro-inflammatory peptide, bradykinin. pKal activity is tightly …
Matriptase drives dissemination of ovarian cancer spheroids by a PAR-2/PI3K/Akt/MMP9 signaling axis
NR Pawar, MS Buzza, N Duru, AA Strong… - Journal of Cell …, 2023 - rupress.org
The transmembrane serine protease matriptase is a key regulator of both barrier-disruptive
and protective epithelial cell–cell interactions. Elevated matriptase is a consistent feature of …
and protective epithelial cell–cell interactions. Elevated matriptase is a consistent feature of …
Why recombinant antibodies—benefits and applications
Antibodies (Abs) are ubiquitous reagents for biological and biochemical research and are
rapidly expanding into new therapeutic areas. They are one of the most important probes for …
rapidly expanding into new therapeutic areas. They are one of the most important probes for …
Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries
DH Nam, C Rodriguez, AG Remacle… - Proceedings of the …, 2016 - National Acad Sciences
Proteases are frequent pharmacological targets, and their inhibitors are valuable drugs in
multiple pathologies. The catalytic mechanism and the active-site fold, however, are largely …
multiple pathologies. The catalytic mechanism and the active-site fold, however, are largely …
Membrane-anchored serine proteases and protease-activated receptor-2–mediated signaling: Co-conspirators in cancer progression
NR Pawar, MS Buzza, TM Antalis - Cancer research, 2019 - AACR
Pericellular proteolysis provides a significant advantage to developing tumors through the
ability to remodel the extracellular matrix, promote cell invasion and migration, and facilitate …
ability to remodel the extracellular matrix, promote cell invasion and migration, and facilitate …
A machine learning approach for hot-spot detection at protein-protein interfaces
R Melo, R Fieldhouse, A Melo, JDG Correia… - International journal of …, 2016 - mdpi.com
Understanding protein-protein interactions is a key challenge in biochemistry. In this work,
we describe a more accurate methodology to predict Hot-Spots (HS) in protein-protein …
we describe a more accurate methodology to predict Hot-Spots (HS) in protein-protein …