The ongoing COVID-19 pandemic has already caused over a million deaths worldwide, and
this death toll will be much higher before effective treatments and vaccines are available …

Over the last two decades, a novel subgroup of serine proteases, the cell surface–anchored
serine proteases, has emerged as an important component of the human degradome, and …

Rapid upregulation of matrix metalloproteinase 9 (MMP-9) leads to blood-brain barrier
(BBB) breakdown following stroke, but no MMP-9 inhibitors have been approved in clinic …

The epidermis is a barrier that prevents water loss while keeping harmful substances from
penetrating the host. The impermeable cornified layer of the stratum corneum is maintained …

Plasma kallikrein (pKal) proteolytically cleaves high molecular weight kininogen to generate
the potent vasodilator and the pro-inflammatory peptide, bradykinin. pKal activity is tightly …

The transmembrane serine protease matriptase is a key regulator of both barrier-disruptive
and protective epithelial cell–cell interactions. Elevated matriptase is a consistent feature of …

Antibodies (Abs) are ubiquitous reagents for biological and biochemical research and are
rapidly expanding into new therapeutic areas. They are one of the most important probes for …

Proteases are frequent pharmacological targets, and their inhibitors are valuable drugs in
multiple pathologies. The catalytic mechanism and the active-site fold, however, are largely …

Pericellular proteolysis provides a significant advantage to developing tumors through the
ability to remodel the extracellular matrix, promote cell invasion and migration, and facilitate …

Understanding protein-protein interactions is a key challenge in biochemistry. In this work,
we describe a more accurate methodology to predict Hot-Spots (HS) in protein-protein …