Endothelium is a community of endothelial cells (ECs), which line the blood and lymphatic
vessels, thus forming an interface between the tissues and the blood or lympha. This …

Mechanical stimuli play a major role in the regulation of skeletal muscle mass, and the
maintenance of muscle mass contributes significantly to disease prevention and issues …

Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disease characterized
by extraskeletal bone formation through endochondral ossification. Patients with FOP harbor …

Resistance training-induced muscle anabolism and subsequent hypertrophy occur most
rapidly during the early phase of training and become progressively slower over time …

The protein kinase mTOR (mechanistic target of rapamycin) in complex 1 (mTORC1)
promotes cell growth and proliferation in response to anabolic stimuli, including growth …

The mammalian target of rapamycin (mTOR) is a protein kinase that, when present in a
complex referred to as mTOR complex 1 (mTORC1), acts as an important regulator of growth …

The mammalian target of rapamycin (mTOR) signalling pathway is a central regulator of
metabolism in all cells. It senses intracellular and extracellular signals and nutrient levels …

Although diacylglycerol kinase α (DGKα) has been linked to several signaling pathways
related to cancer cell biology, it has been neglected as a target for cancer therapy. The …

Skeletal muscles have a fundamental role in locomotion and whole body metabolism, with
muscle mass and quality being linked to improved health and even lifespan. Optimizing …

Signaling by mTOR is a well-recognized component of the pathway through which
mechanical signals regulate protein synthesis and muscle mass. However, the mechanisms …