The basics of thiols and cysteines in redox biology and chemistry
LB Poole - Free Radical Biology and Medicine, 2015 - Elsevier
Cysteine is one of the least abundant amino acids, yet it is frequently found as a highly
conserved residue within functional (regulatory, catalytic, or binding) sites in proteins. It is …
conserved residue within functional (regulatory, catalytic, or binding) sites in proteins. It is …
[HTML][HTML] Integration of machine learning and genome-scale metabolic modeling identifies multi-omics biomarkers for radiation resistance
Resistance to ionizing radiation, a first-line therapy for many cancers, is a major clinical
challenge. Personalized prediction of tumor radiosensitivity is not currently implemented …
challenge. Personalized prediction of tumor radiosensitivity is not currently implemented …
Biological chemistry and functionality of protein sulfenic acids and related thiol modifications
NO Devarie-Baez, EI Silva Lopez… - Free radical …, 2016 - Taylor & Francis
Selective modification of proteins at cysteine residues by reactive oxygen, nitrogen or sulfur
species formed under physiological and pathological states is emerging as a critical …
species formed under physiological and pathological states is emerging as a critical …
High‐Z‐Sensitized Radiotherapy Synergizes with the Intervention of the Pentose Phosphate Pathway for In Situ Tumor Vaccination
Y Wang, J Chen, R Duan, R Gu, W Wang… - Advanced …, 2022 - Wiley Online Library
In situ tumor vaccination is preliminarily pursued to strengthen antitumor immune response.
Immunogenic tumor cell death spontaneously releases abundant antigens and adjuvants for …
Immunogenic tumor cell death spontaneously releases abundant antigens and adjuvants for …
Energy metabolism in a matched model of radiation resistance for head and neck squamous cell cancer
While radiation therapy is commonly used for treating cancer, radiation resistance can limit
long-term control of the disease. In this study, we investigated the reprogramming of the …
long-term control of the disease. In this study, we investigated the reprogramming of the …
[HTML][HTML] Personalized genome-scale metabolic models identify targets of redox metabolism in radiation-resistant tumors
Redox cofactor production is integral toward antioxidant generation, clearance of reactive
oxygen species, and overall tumor response to ionizing radiation treatment. To identify …
oxygen species, and overall tumor response to ionizing radiation treatment. To identify …
Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors
Resistance to radiation therapy constitutes a significant challenge in the treatment of head
and neck squamous cell cancer (HNSCC). Alteration in DNA methylation is thought to play a …
and neck squamous cell cancer (HNSCC). Alteration in DNA methylation is thought to play a …
[HTML][HTML] Wnt signaling induces radioresistance through upregulating HMGB1 in esophageal squamous cell carcinoma
Y Zhao, J Yi, L Tao, G Huang, X Chu, H Song… - Cell death & …, 2018 - nature.com
Although many articles have uncovered that Wnt signaling is involved in radioresistance, the
mechanism is rarely reported. Here we generated two radioresistant cells rECA109 and …
mechanism is rarely reported. Here we generated two radioresistant cells rECA109 and …
p53/BNIP3-dependent mitophagy limits glycolytic shift in radioresistant cancer
HW Chang, MR Kim, HJ Lee, HM Lee, GC Kim, YS Lee… - Oncogene, 2019 - nature.com
The role of p53 in genotoxic therapy-induced metabolic shift in cancers is not yet known. In
this study, we investigated the role of p53 in the glycolytic shift in head and neck squamous …
this study, we investigated the role of p53 in the glycolytic shift in head and neck squamous …
[HTML][HTML] Peroxiredoxins in cancer and response to radiation therapies
Peroxiredoxins have a long-established cellular function as regulators of redox metabolism
by catalyzing the reduction of peroxides (eg, H2O2, lipid peroxides) with high catalytic …
by catalyzing the reduction of peroxides (eg, H2O2, lipid peroxides) with high catalytic …