Cysteine is one of the least abundant amino acids, yet it is frequently found as a highly
conserved residue within functional (regulatory, catalytic, or binding) sites in proteins. It is …

Resistance to ionizing radiation, a first-line therapy for many cancers, is a major clinical
challenge. Personalized prediction of tumor radiosensitivity is not currently implemented …

Selective modification of proteins at cysteine residues by reactive oxygen, nitrogen or sulfur
species formed under physiological and pathological states is emerging as a critical …

In situ tumor vaccination is preliminarily pursued to strengthen antitumor immune response.
Immunogenic tumor cell death spontaneously releases abundant antigens and adjuvants for …

While radiation therapy is commonly used for treating cancer, radiation resistance can limit
long-term control of the disease. In this study, we investigated the reprogramming of the …

Redox cofactor production is integral toward antioxidant generation, clearance of reactive
oxygen species, and overall tumor response to ionizing radiation treatment. To identify …

Resistance to radiation therapy constitutes a significant challenge in the treatment of head
and neck squamous cell cancer (HNSCC). Alteration in DNA methylation is thought to play a …

Although many articles have uncovered that Wnt signaling is involved in radioresistance, the
mechanism is rarely reported. Here we generated two radioresistant cells rECA109 and …

The role of p53 in genotoxic therapy-induced metabolic shift in cancers is not yet known. In
this study, we investigated the role of p53 in the glycolytic shift in head and neck squamous …

Peroxiredoxins have a long-established cellular function as regulators of redox metabolism
by catalyzing the reduction of peroxides (eg, H2O2, lipid peroxides) with high catalytic …