Chromosome segregation during cell division requires a bipolar mitotic spindle. Therefore,
how the spindle is formed, maintained, and functions is of fundamental importance for all …

Anaphase B spindle elongation is characterized by the sliding apart of overlapping
antiparallel interpolar (ip) microtubules (MTs) as the two opposite spindle poles separate …

Cell fate of mitotic cell is controlled by spindle assembly. Deficient spindle assembly results
in mitotic catastrophe leading to cell death to maintain cellular homeostasis. Therefore …

Navigation of the growth cone at the tip of the developing axon is crucial for the proper
wiring of the nervous system. Mechanisms of actin-dependent growth cone steering, via …

A facilitative transport system exists on the blood–brain barrier (BBB) that has been tacitly
assumed to be a path for glutamate entry to the brain. However, glutamate is a non-essential …

Several kinesin-5 motors (kinesin-5s) exhibit bidirectional motility. The mechanism of such
motility remains unknown. Bidirectional kinesin-5s share a long N-terminal nonmotor …

Kinesin‐5 motors fulfil essential roles in mitotic spindle morphogenesis and dynamics as
slow, processive microtubule (MT) plus‐end directed motors. The Saccharomyces …

In this study, we examined the anaphase functions of the S. cerevisiae kinesin-5 homolog
Kip1. We show that Kip1 is attached to the mitotic spindle midzone during late anaphase …

Architectural integrity of the mitotic spindle is required for efficient chromosome congression
and accurate chromosome segregation to ensure mitotic fidelity. Tumour suppressor PTEN …

Mitotic cell division is the most fundamental task of all living cells. Cells have intricate and
tightly regulated machinery to ensure that mitosis occurs with appropriate frequency and …