The importance of safer approaches for gene therapy has been underscored by a series of
severe adverse events (SAEs) observed in patients involved in clinical trials for Severe …

Homing endonucleases are microbial DNA-cleaving enzymes that mobilize their own
reading frames by generating double strand breaks at specific genomic invasion sites …

Genetic mutations or engineered nucleases that disrupt the HIV co-receptor CCR5 block HIV
infection of CD4+ T cells. These findings have motivated the engineering of CCR5-specific …

Genetic methods of manipulating or eradicating disease vector populations have long been
discussed as an attractive alternative to existing control measures because of their potential …

Rare-cleaving endonucleases have emerged as important tools for making targeted
genome modifications. While multiple platforms are now available to generate reagents for …

Homing endonucleases are highly specific DNA cleaving enzymes that are encoded within
genomes of all forms of microbial life including phage and eukaryotic organelles. These …

Mosquito-borne pathogens place an enormous burden on human health. The existing toolkit
is insufficient to support ongoing vector-control efforts towards meeting disease elimination …

The ability to manipulate the genome with precise spatial and nucleotide resolution
(genome editing) has been a powerful research tool. In the past decade, the tools and …

Buried within the genomes of many microorganisms are genetic elements that encode rare-
cutting homing endonucleases that assist in the mobility of the elements that encode them …

Homing endonucleases are strong drivers of genetic exchange and horizontal transfer of
both their own genes and their local genetic environment. The mechanisms that govern the …