Most systems biology approaches involve determining the structure of biological circuits
using genomewide"-omic" analyses. Yet imaging offers the unique advantage of watching …

Novel approaches to bio‐imaging and automated computational image processing allow the
design of truly quantitative studies in developmental biology. Cell behavior, cell fate …

The notochord is a structure required for support and patterning of all chordate embryos,
from sea squirts to humans. An increasing amount of information on notochord development …

Chordate embryos show an evolutionary trend in the mechanisms they use to internalize
presumptive mesoderm, relying predominantly on invagination in the basal chordates …

A central challenge of developmental and evolutionary biology is to explain how anatomy is
encoded in the genome. Anatomy emerges progressively during embryonic development …

During early Drosophila embryogenesis, a network of gene regulatory interactions
orchestrates terminal patterning, playing a critical role in the subsequent formation of the gut …

The notochord is a defining feature of the chordate body plan. Experiments in ascidian, frog
and mouse embryos have shown that co-expression of Brachyury and FoxA class …

Gene regulatory networks control the progressive specification of cell types and govern
morphogenetic events during development. However, how morphogenetic events …

Ascidians are invertebrate chordates that form tadpole larvae with a surprisingly small
number of cells. Recently, the emergence of powerful molecular tools to study cell fate …

Developmental biology relies heavily on microscopy to image the finely controlled cell
behaviors that drive embryonic development. Most embryos are large enough that a field of …