Background Ketamine appears to have a therapeutic role in certain mental disorders, most
notably depression. However, the comparative performance of different formulations of …

Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …

Abstract Treatment-resistant depression (TRD) is a subset of Major Depressive Disorder
which does not respond to traditional and first-line therapeutic options. There are several …

This is the first systematic review of the safety of ketamine in the treatment of depression
after single and repeated doses. We searched MEDLINE, PubMed, PsycINFO, and …

Depression is the third leading cause of disability in the world. Depressive symptoms may
be reduced within several weeks after the start of conventional antidepressants, but …

Ketamine, a commonly used general anesthetic, can produce rapid and sustained
antidepressant effect. However, the efficacy and safety of the perioperative application of …

Objective We investigated the comparative efficacy and tolerability of pharmacological
treatment strategies for the treatment of acute bipolar depression. Data sources A systematic …

CD38 is involved in immune responses, cell proliferation, and has been identified in the
brain, where it is implicated in inflammation processes and psychiatric disorders. We …

Background Racemic ketamine and esketamine have demonstrated rapid antidepressant
effects. We aimed to review the efficacy and safety of racemic and esketamine for …

Background The effectiveness, tolerability, and safety of intravenous (IV) ketamine in adults
with treatment resistant depression (TRD) receiving care in real-word settings is insufficiently …