Polyphosphoinositide binding domains: Key to inositol lipid biology
GRV Hammond, T Balla - Biochimica Et Biophysica Acta (BBA)-Molecular …, 2015 - Elsevier
Polyphosphoinositides (PPIn) are an important family of phospholipids located on the
cytoplasmic leaflet of eukaryotic cell membranes. Collectively, they are critical for the …
cytoplasmic leaflet of eukaryotic cell membranes. Collectively, they are critical for the …
Dynamic shaping of cellular membranes by phospholipids and membrane-deforming proteins
S Suetsugu, S Kurisu, T Takenawa - Physiological reviews, 2014 - journals.physiology.org
All cellular compartments are separated from the external environment by a membrane,
which consists of a lipid bilayer. Subcellular structures, including clathrin-coated pits …
which consists of a lipid bilayer. Subcellular structures, including clathrin-coated pits …
[HTML][HTML] Modular detection of GFP-labeled proteins for rapid screening by electron microscopy in cells and organisms
Reliable and quantifiable high-resolution protein localization is critical for understanding
protein function. However, the time required to clone and characterize any protein of interest …
protein function. However, the time required to clone and characterize any protein of interest …
[HTML][HTML] Protein homeostasis in aging and cancer
XQ Chen, T Shen, SJ Fang, XM Sun, GY Li… - Frontiers in Cell and …, 2023 - frontiersin.org
Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis,
or proteostasis, is a universal hallmark of both the aging process and cancer, a …
or proteostasis, is a universal hallmark of both the aging process and cancer, a …
Phosphoinositide 3-kinase (PI3K) classes: From cell signaling to endocytic recycling and autophagy
A Safaroghli-Azar, MJ Sanaei… - European Journal of …, 2023 - Elsevier
Lipid signaling is defined as any biological signaling action in which a lipid messenger
binds to a protein target, converting its effects to specific cellular responses. In this complex …
binds to a protein target, converting its effects to specific cellular responses. In this complex …
[HTML][HTML] Class II PI3Ks at the intersection between signal transduction and membrane trafficking
Phosphorylation of inositol phospholipids by the family of phosphoinositide 3-kinases
(PI3Ks) is crucial in controlling membrane lipid composition and regulating a wide range of …
(PI3Ks) is crucial in controlling membrane lipid composition and regulating a wide range of …
Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCα invasive signaling axis
D Hoshino, J Jourquin, SW Emmons, T Miller… - Science …, 2012 - science.org
In cancer, deregulated signaling can produce an invasive cellular phenotype. We modeled
the invasive transition as a theoretical switch between two cytoskeletal structures: focal …
the invasive transition as a theoretical switch between two cytoskeletal structures: focal …
[HTML][HTML] PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction
The spatial restriction of phosphorylated phosphoinositides generated downstream
activated membrane receptors is critical for proper cell response to environmental cues. The …
activated membrane receptors is critical for proper cell response to environmental cues. The …
[HTML][HTML] Signaling roles of phosphoinositides in the retina
RVS Rajala - Journal of lipid research, 2021 - ASBMB
The field of phosphoinositide signaling has expanded significantly in recent years.
Phosphoinositides (also known as phosphatidylinositol phosphates or PIPs) are universal …
Phosphoinositides (also known as phosphatidylinositol phosphates or PIPs) are universal …
Microscopic methods to observe the distribution of lipids in the cellular membrane
S Takatori, R Mesman, T Fujimoto - Biochemistry, 2014 - ACS Publications
Membrane lipids not only provide the structural framework of cellular membranes but also
influence protein functions in several different ways. In comparison to proteins, however …
influence protein functions in several different ways. In comparison to proteins, however …