Polyphosphoinositides (PPIn) are an important family of phospholipids located on the
cytoplasmic leaflet of eukaryotic cell membranes. Collectively, they are critical for the …

All cellular compartments are separated from the external environment by a membrane,
which consists of a lipid bilayer. Subcellular structures, including clathrin-coated pits …

Reliable and quantifiable high-resolution protein localization is critical for understanding
protein function. However, the time required to clone and characterize any protein of interest …

Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis,
or proteostasis, is a universal hallmark of both the aging process and cancer, a …

Lipid signaling is defined as any biological signaling action in which a lipid messenger
binds to a protein target, converting its effects to specific cellular responses. In this complex …

Phosphorylation of inositol phospholipids by the family of phosphoinositide 3-kinases
(PI3Ks) is crucial in controlling membrane lipid composition and regulating a wide range of …

In cancer, deregulated signaling can produce an invasive cellular phenotype. We modeled
the invasive transition as a theoretical switch between two cytoskeletal structures: focal …

The spatial restriction of phosphorylated phosphoinositides generated downstream
activated membrane receptors is critical for proper cell response to environmental cues. The …

The field of phosphoinositide signaling has expanded significantly in recent years.
Phosphoinositides (also known as phosphatidylinositol phosphates or PIPs) are universal …

Membrane lipids not only provide the structural framework of cellular membranes but also
influence protein functions in several different ways. In comparison to proteins, however …