Covering: up to the beginning of 2020 Enzymes depending on cofactors are essential in
many biosynthetic pathways of natural products. They are often involved in key steps …

In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent
methyltransferases and SAM are evaluated. Their structural classification and diversity is …

Cascade reactions catalyzed by multienzymatic systems have strongly moved into the focus
of researchers in the field of biocatalysis because of their unique potential for the …

The combination of sequential biocatalytic reactions, via non-natural synthetic cascades, is a
rapidly developing field and leads to the generation of complex valuable chemicals from …

S‐Adenosylmethionine‐dependent methyltransferases are versatile tools for the specific
alkylation of many compounds, such as pharmaceuticals, but their biocatalytic application is …

The ability to site-selectively modify equivalent functional groups in a molecule has the
potential to streamline syntheses and increase product yields by lowering step counts …

Metagenomic sequencing data provide a rich resource from which to expand our
understanding of differential protein functions involved in human health. Here, we outline a …

The ubiquitous cofactor S-adenosyl-L-methionine (SAM) is part of numerous biochemical
reactions in metabolism, epigenetics, and cancer development. As methylation usually …

Benzylisoquinoline alkaloid derived pharmaceuticals are widely applied in modern
medicines. Recent studies on the microbial production of benzylisoquinolines have …

The application of chalcogenonium salts in organic synthesis has grown enormously in the
past decades since the discovery of the methyltransferase enzyme cofactor S-adenosyl-L …