Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in
antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent …

Neutrophils are the most abundant white blood cells in circulation, and patients with
congenital neutrophil deficiencies suffer from severe infections that are often fatal …

Neutrophils are an important component of the innate immune system and provide a front
line of defense against bacterial infection. Although most bacteria are killed readily by …

Neutrophils (also called polymorphonuclear leukocytes, PMNs) are the most abundant white
blood cells in humans and play a central role in innate host defense. Another distinguishing …

Mycobacterium tuberculosis' success as a pathogen comes from its ability to evade
degradation by macrophages. Normally macrophages clear microorganisms that activate …

The production of reactive oxygen species (ROS) within immune cell phagosomes is critical
for antimicrobial activity and for correct antigen processing, and influences signaling …

Francisella tularensis is a zoonotic intracellular pathogen and the causative agent of the
debilitating febrile illness tularemia. Although natural infections by F. tularensis are sporadic …

Neutrophils are the first line of defense against bacterial infections, and the generation of
reactive oxygen species is a key part of their arsenal. Pathogens use detoxification systems …

Neutrophils or polymorphonuclear neutrophils (PMNs) are an important component of innate
host defense. These phagocytic leukocytes are recruited to infected tissues and kill invading …

Francisella tularensis is a Gram-negative intracellular pathogen and the causative agent of
the disease tularemia. Inhalation of as few as 10 bacteria is sufficient to cause severe …