When present in the extracellular environment, the nucleoside adenosine protects cells and
tissues from excessive inflammation and immune-mediated damage while promoting …

There is widespread involvement of purinergic signalling in endocrine biology. Pituitary cells
express P1, P2X and P2Y receptor subtypes to mediate hormone release. Adenosine 5 …

Glucagon, a hormone released from pancreatic α-cells, is critical for maintaining euglycemia
and plays a key role in the pathophysiology of diabetes. To stimulate the development of …

Prediabetic NOD mice exhibit hyperglucagonemia, possibly due to an intrinsic α-cell defect.
Here, we show that the expression of a potential glucagon inhibitor, the adenosine A1 …

Adenosine A1, A2A, A2B and A3 receptor mRNAs were found to be expressed in mouse
pancreatic islets and Beta-TC6 cells but their physiological or pharmacological actions are …

In addition to its central role controlling systemic calcium homeostasis, the extracellular
calcium-sensing receptor (CaSR) can be found on multiple cell types not associated with …

Background Cortical brain slices offer a readily accessible experimental model of a region of
the brain commonly affected by epilepsy. The diversity of recording techniques, seizure …

Diabetes mellitus encompasses two distinct disease processes: autoimmune Type 1 (T1D)
and nonimmune Type 2 (T2D) diabetes. Despite the disparate aetiologies, the disease …

Type 2 diabetes mellitus (T2DM) is characterized by the inability of the pancreatic β-cells to
secrete enough insulin to meet the demands of the body. Therefore, research of potential …

Under physiological conditions, insulin secretion from pancreatic β-cells is tightly regulated
by different factors, including nutrients, nervous system, and other hormones. Pancreatic β …