Advances in Babesia Vaccine Development: An Overview

M Jerzak, A Gandurski, M Tokaj, W Stachera, M Szuba… - Pathogens, 2023 - mdpi.com
Babesiosis is a tick-borne zoonotic disease, which is caused by various species of
intracellular Babesia parasite. It is a problem not only for the livestock industry but also for …

A vaccine for human babesiosis: Prospects and feasibility

H Al-Nazal, LM Low, S Kumar, MF Good… - Trends in Parasitology, 2022 - cell.com
Babesiosis is a tick-borne disease caused by intraerythrocytic Babesia parasites. It is a well-
known illness in companion animals and livestock, resulting in substantial economic losses …

Kinetics of the invasion and egress processes of Babesia divergens, observed by time-lapse video microscopy

E Sevilla, LM González, D Luque, J Gray, E Montero - Scientific Reports, 2018 - nature.com
Based on confocal fluorescence and bright field video microscopy, we present detailed
observations on the processes of invasion and egress of erythrocytes by the apicomplexan …

[HTML][HTML] A library of recombinant Babesia microti cell surface and secreted proteins for diagnostics discovery and reverse vaccinology

CM Elton, M Rodriguez, CB Mamoun, CA Lobo… - International journal for …, 2019 - Elsevier
Human babesiosis is an emerging tick-borne parasitic disease and blood transfusion-
transmitted infection primarily caused by the apicomplexan parasite, Babesia microti. There …

Babesia bovis RON2 contains conserved B-cell epitopes that induce an invasion-blocking humoral immune response in immunized cattle

M Hidalgo-Ruiz, CE Suarez, MA Mercado-Uriostegui… - Parasites & vectors, 2018 - Springer
Background Babesia bovis belongs to the phylum Apicomplexa and is the major causal
agent of bovine babesiosis, the most important veterinary disease transmitted by arthropods …

Evidence for vesicle-mediated antigen export by the human pathogen Babesia microti

J Thekkiniath, N Kilian, L Lawres… - Life Science …, 2019 - life-science-alliance.org
The apicomplexan parasite Babesia microti is the primary agent of human babesiosis, a
malaria-like illness and potentially fatal tick-borne disease. Unlike its close relatives, the …

A conserved protein of Babesia microti elicits partial protection against Babesia and Plasmodium infection

Y Wang, Q Zhang, W Zhang, J Chen, J Dai, X Zhou - Parasites & Vectors, 2023 - Springer
Abstract Background The protozoan parasite Babesia microti that causes the zoonotic
disease babesiosis resides in the erythrocytes of its mammalian host during its life-cycle. No …

Babesia bovis RON2 binds to bovine erythrocytes through a highly conserved epitope

L Cuy-Chaparro, D Barney-Borrero… - Veterinary …, 2024 - Elsevier
B. bovis invasion of bovine erythrocytes requires tight junction formation involving AMA-
1/RON2 complex interaction. RON2 has been considered a vaccine candidate since …

Babesia microti Protein BmSP44 Is a Novel Protective Antigen in a Mouse Model of Babesiosis

H Wang, Y Wang, J Huang, B Xu, J Chen… - Frontiers in …, 2020 - frontiersin.org
Babesiosis caused by Babesia species imposes an increasing threat to public-health and so
far, there is no effective vaccine to prevent Babesia infections. Babesia surface antigen may …

RON2, a novel gene in Babesia bigemina, contains conserved, immunodominant B-cell epitopes that induce antibodies that block merozoite invasion

J Mosqueda, M Hidalgo-Ruiz, DA Calvo-Olvera… - Parasitology, 2019 - cambridge.org
Bovine babesiosis is the most important protozoan disease transmitted by ticks. In
Plasmodium falciparum, another Apicomplexa protozoan, the interaction of rhoptry neck …