Replication stress is a major cause of genomic instability and a crucial vulnerability of
cancer cells. This vulnerability can be therapeutically targeted by inhibiting kinases that …

Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

Hematologic malignancies include various diseases that develop from hematopoietic stem
cells of bone marrow or lymphatic organs. Currently, conventional DNA-damage-based …

The tumor suppressor p53 plays a critical role to preserve DNA fidelity from diverse insults
through the regulation of cell-cycle checkpoints, DNA repair, senescence and apoptosis …

PURPOSE AZD1775 (adavosertib) is an inhibitor of the Wee1 kinase. In this study, we built
on our preclinical studies to evaluate the safety and efficacy of AZD1775 in combination with …

Wee1 is a protein kinase that regulates the G2 checkpoint and prevents entry into mitosis in
response to DNA damage. Cyclin-dependent kinases (CDK) are a family of 14 …

KRAS mutations in non–small cell lung cancer (NSCLC) cause increased levels of DNA
damage and replication stress, suggesting that inhibition of the DNA damage response …

Cancer cells typically heavily rely on the G2/M checkpoint to survive endogenous and
exogenous DNA damage, such as genotoxic stress due to genome instability or radiation …

Radiotherapy is widely used in the clinical treatment of cancer patients and it may be used
alone or in combination with surgery or chemotherapy to inhibit tumor development …

Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) are noncoding RNAs
(ncRNAs) that occupy over 90% of the human genome, and their main function is to directly …